Kenneth A. Wilson, PhD

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in mice

Makhijani P, Emani R, Galicia Aguirre C, Mu W, Rane A, Ng JHY, Valentino TR, Manwaring-Mueller M, Tan CR, Du H, Wu F, Khan S, Wilson KA, Winer S, Wang C, Mortha A, Furman D, Ellerby LM, Rohas OL, Andersen JK, Winer DA

Cell Reports (under review)

Neuronal glycogen breakdown mitigates tauopathy via pentose phosphate pathway-mediated oxidative stress reduction

Bar S, Wilson KA, Hilsabeck TAU, Alderfer S, Dammer EB, Burton JB, Shah S, Holtz A, Carrera EM, Beck JN, Chen J, Kauwe G, Seifar F, Shantaraman A, Tracy T, Seyfried NT, Schilling B, Ellerby LM, Kapahi P

Nature Metabolism, In Press, 2025

OXR1 maintains the retromer to delay brain aging under dietary restriction

Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW, Beck JN, Rose J, Granath-Panelo M, Nelson CS, Qi G, Gerencser A, Lan J, Afenjar A, Chawla G, Brem RB, Campeau PM, Bellen HJ, Schilling B, Seyfried NT, Ellerby LM, Kapahi P

Nature Communications, vol. 15(1), 2024, p. 467

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans

Hilsabeck TAU, Narayan V, Wilson KA, Carrera EM, Raftery D, Promislow DEL, Brem RB, Campisi J, Kapahi P

Nature Communications, vol. 15(1), 2024, p. 9330

Longitudinal fundus imaging and its genome-wide association analyses provide evidence for a human retinal aging clock

Ahadi S, Wilson KA, Babenko B, McLean CY, Bryant D, Pritchard O, Kumar A, Carrera EM, Lamy R, Stewart JM, Varadarajan A, Berndl M, Kapahi P, Bashir A

eLife, vol. 12, 2023, pp. e82364

A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response

Hilsabeck TAU, Liu-Bryan R, Guo T, Wilson KA, Bose N, Raftery D, Beck JN, Lang S, Jin K, Nelson CS, Oron T, Stoller M, Promislow DEL, Brem RB, Turkeltaub R, Kapahi P

GeroScience, vol. 44(22), 2022, pp. 2195-2211

Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

Kim SJ, Devgan A, Miller B, Lee SM, Kumagai H, Wilson KA, Wassef G, Wong R, Mehta HH, Cohen P, Yen K

Biochimica et Biophysica Acta – General Subjects, vol. 1866(1), 2022, p. 130017

Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila

Sharma A, Akagi K, Pattavina B, Wilson KA, Nelson C, Watson M, Maksoud E, Harata A, Ortega M, Brem RB, Kapahi P

Scientific Reports, vol. 10(1), 2022, pp. 1-10

Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

Jin K, Wilson KA, Beck JN, Nelson CS, Brownridge GW, Harrison BR, Djukovic D, Raftery D, Brem RB, Yu S, Drton M, Shojaie A, Kapahi P, Promislow D

PLOS Genetics, vol. 16(7), 2020, pp. e1008835

GWAS for lifespan and decline in climbing ability in flies upon dietary restriction reveal decima as a mediator of insulin-like peptide production

Wilson KA, Beck JN, Nelson CS, Hilsabeck TA, Promislow D, Brem RB, Kapahi P

Current Biology, vol. 30(14), 2020, pp. 2749-2760

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Lang S, Hilsabeck TH, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P

PLOS Genetics, vol. 15(8), 2018, p. 31008318

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Akagi K, Wilson KA, Katewa SD, Ortega M, Simons J, Hilsabeck TA, Kapuria S, Sharma A, Jasper H, Kapahi P

PLOS Genetics, vol. 14(11), 2018, pp. e1007777

Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila

Nelson CS*, Beck JN*, Wilson KA* (* co-lead author), Pilcher ER, Kapahi P, Brem RB

BMC Genomics, vol. 17(1), 2016, pp. 1-14

The understudied links of the retromer complex to age-related pathways

Wilson KA

GeroScience, vol. 44(1), 2022, pp. 19-24

Ketones to the rescue of the starving fly

Wilson KA, Bar S, Kapahi P

Nature Metabolism, vol. 4(2), 2022, pp. 159-160

Haste makes waste: The significance of translation fidelity for development and longevity

Wilson KA, Bar S, Kapahi P

Molecular Cell, vol. 81(18), 2021, pp. 3675-3676

Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience

Wilson KA, Chamoli M, Hilsabeck TA, Pandey M, Bansal S, Chawla G, Kapahi P

Cell Metabolism, vol. 33(11), 2021, pp. 2142-2173

Drosophila gut – A nexus between dietary restriction and lifespan

Lian T, Wu Q, Hodge BA, Wilson KA, Yu G, Yang M

International Journal of Molecular Sciences, vol. 19(12), 2018, p. 3810

Untitled

Intervertebral disc impairments in a mouse model of Alzheimer’s Disease

BioRxiv, 2025

The role of natural genetic variation in the regulation of dietary restriction-mediated longevity and health

Wilson KA

University of Southern California, 2019 Aug

Mapping Natural Genetic Variants Associated with Nutrient Response

Wilson KA

Dominican University of California, 2014 May